TABLE 1.
Physical and hemolytic properties of a liposomal AMB formulation prepared from DSHemsPC
| AMB formulation | Avg liposome size ± SD (nm) | Mean polydispersity ± SD | Mean zeta potential ± SD (mV) | Hemolysis IC50 (mg/ml)a |
|---|---|---|---|---|
| DSHemsPC-DMPC-DMPG-AMB | 111.6 ± 1.0 | 0.21 ± 0.02 | −25.3 ± 9.05 | 42.6 (16.7–278.4) |
| DSHemsPC-DMPC-DMPG | 76.9 ± 0.4 | 0.21 ± 0.06 | −42.7 ± 0.5 | Inactive |
| AmBisome | 120.3 ± 1.5 | 0.2 ± 0.2 | −54.5 ± 1.1 | 11.6 (0.14–971) |
| Fungizone | 0.077 (0.0018–9.32) |
a
The values in parentheses are the lower and upper 95% limits. The IC50 of the DSHemsPC-AMB liposomal formulation was significantly (P < 0.001) greater than that of AmBisome and Fungizone; the IC50 of AmBisome was also significantly (P < 0.01) greater than that of Fungizone.