TABLE 2.
AMB concentration in serum and selected tissues following i.v. injection of DSHemsPC-AMB-Lip and AmBisome in uninfected (healthy) BALB/c mice
| Formulation | Mean concn ± SDa |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Tissues |
Serum |
||||||||
| Heart | Liver | Kidney | Spleen | Lung | 1 h | 6 h | 12 h | 24 h | |
| DSHemsPC-AMB-Lip | 44.2 ± 9.2 | 0.4 ± 0.2 | 16.5 ± 4.1 | 2.1 ± 2.1 | 34.1 ± 0.2 | 6.3 ± 2.3 | 1.7 ± 0.03 | 1.7 ± 0.01 | |
| AmBisomeb | 0.4 ± 0.2 | 36.8 ± 9.9 | 1 ± 0.9 | 13.8 ± 2.8 | 1.5 ± 0.6 | 36 ± 0.15 | 9.8 ± 2.2 | 2.2 ± 0.5 | 1.9 ± 0.01 |
Each value is the mean concentration ± standard deviation for three animals. Concentrations are in micrograms per gram of tissue for heart, liver, kidney, spleen, and lung tissues and micrograms per milliliter for serum. No drug was detected in serum and tissues from experimental animals receiving 5% dextrose. The serum AMB concentrations at each time were not significantly different (P > 0.05) among DSHemsPC-AMB-Lip- and AmBisome-treated mice. The AMB concentrations in each tissue were not significantly different (P > 0.05) among DSHemsPC-AMB-Lip- and AmBisome-treated mice.
AmBisome was administered at 10 mg/kg.