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. 2017 Jul 18;38(4):180–190. doi: 10.24272/j.issn.2095-8137.2017.045

Figure 3.

A: Flow chart for lentivirus preparation; B: Viral injection design in dorsal areas of tree shrew skin; C: Representative images under different magnifications (4×, 10×, 20×, 40×) with HE staining. Results showed BCC-like hyperplasia of skin cells with hair follicle (HF) disruption (arrow head), pigmentation (asterisk), and nuclear explosion expansion after viral injection two weeks later. The pCDH-vector served as the control viral injection.

Over-expression of SmoA1 induced BCC-like hyperplasia in dorsal skins of the tree shrews in vivo