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. 2017 Apr 14;21(9):1929–1943. doi: 10.1111/jcmm.13114

Figure 4.

Figure 4

miR‐495 sensitized MDR cells to taxol‐doxorubicin mixtures. To promote the toxic effect of drugs on MDR cancer cells, the MDR1 expression in cells resistant to the taxol‐doxorubicin mixture was suppressed by transfecting the cells with the miR‐495 mimic. (A) Relative miR‐495 levels in the cell lines A2780DX5 and SGC7901R and the cisplatin‐resistant cell line A2780C. (B) The sensitivity to taxol was assayed by flow cytometry to measure cell apoptosis after the cells were transfected with the miR‐495 mimic. (C) The quantification of cell apoptosis. The miR‐495 mimic increased the taxol‐doxorubicin‐induced cell apoptosis but had less of an effect on the cisplatin‐treated cells. *Student's t‐test (paired, one tailed), P < 0.05, n = 5.