Figure 5.

Schematic representation of a possible correlation between ColXV expression levels and mineral matrix deposition in hMSCs with different status of maturation and in hOBs that are able to grow in culture medium with or without calcium. Nearly constant expression of ColXV in those hMSCs which osteo‐differentiated but did not produce a completely calcified matrix could be useful to keep cells in a prone and responsive state to osteogenic differentiation stimuli, allowing bone remodelling or regeneration. Conversely, cells at the end of differentiation, such as osteoblasts or completely osteo‐differentiated hMSCs, are present in a completely calcified extracellular matrix with low or undetectable levels of ColXV.