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Effect of tolvaptan on AQP2 localization in MDCK‐hAQP2 cells. MDCK cells were grown on filters and were exposed to different treatments. AQP2 was localized by confocal microscopy. Stimulation with dDAVP caused AQP2 translocation to the apical plasma membrane. In contrast, tolvaptan prevented dDAVP‐induced AQP2 redistribution (dDAVP+TLV). Apparently tolvaptan did not prevent the re‐localization of the bulk of AQP2 to the apical membrane in response to FK.
