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JAK/STAT pathway. A cytokine stimulates the cell surface receptor and activates the associated Janus kinase (JAK). This protein autophosphorylates and binds to a STAT (signal transducer and activator of transcription) protein, which is in turn itself is phosphorylated. The STAT protein then dimerizes and translocates into the nucleus of the cell. Here, it binds to DNA at a promoter site and causes gene transcription.
