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. 2017 Feb 28;21(9):1791–1802. doi: 10.1111/jcmm.13100

Figure 4.

Figure 4

CBX reduces acrolein‐induced cell injury through inhibition of oxidative stress and P38 activation. (A–B) Effects of CBX on cell viability. Urothelial cells were incubated with 100 μM acrolein for 12 hrs in the presence or absence of 10 μM CBX. Then, the cells were stained with PI (A) and cell supernatants were collected for LDH assay (B). Data are expressed as mean ± S.E. (n = 3). *P < 0.01. (C–D) Effect of CBX on acrolein‐induced protein carbonylation and P38 activation. Urothelial cells were exposed to 100 μM acrolein for 3 hrs in the presence or absence of CBX. Then, cell lysates were assayed for carbonylated proteins (C) and P38 phosphorylation (D).