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. 2017 Apr 21;21(9):2163–2171. doi: 10.1111/jcmm.13140

Figure 2.

Figure 2

Effects of IL‐18 on NSC proliferation and differentiation. (A) The proliferation of NSCs incubated with increasing concentrations of IL‐18 (1–100 ng/ml) was measured by CCK‐8 assay. (B) The time‐dependent effect of IL‐18 (10 ng/ml) on NSC proliferation was measured by CCK‐8 assay. (C) IL‐18 concentration‐dependent neurosphere formation. (D) Nestin protein expression was detected by Western blots. (E) Effects of IL‐18 (10 ng/ml) on β‐tubulin‐III‐positive cells in NSC culture. (F) Effects of IL‐18 (10 ng/ml) on β‐tubulin‐III mRNA expression. (G) Effects of IL‐18 (10 ng/ml) on β‐tubulin‐III protein expression. *P < 0.05 and ***P < 0.001.