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. 2017 Apr 21;21(9):2163–2171. doi: 10.1111/jcmm.13140

Figure 3.

Figure 3

Effects of melatonin on the NSC proliferation and differentiation. (A) The proliferation of NSCs incubated with or without IL‐18 (10 ng/ml) in the presence or absence of melatonin (10 ng/ml). (B) Melatonin increased neurosphere formation in the presence or absence of IL‐18 and melatonin. (C) Nestin expression in IL‐18‐challenged NSCs with or without melatonin. (D) Immunofluorescence staining for β‐tubulin‐III‐positive neurons derived from NSCs incubated with or without IL‐18 (10 ng/ml) and melatonin (10 ng/ml). (E–F) Effects of melatonin on β‐tubulin‐III (E) mRNA and (F) protein expression in IL‐18‐challenged NSCs. *P < 0.05; **P < 0.01; ***P < 0.001.