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Effects of TrkB‐Fcon protective actions of melatonin in IL‐18‐challenged NSCs. (A) The proliferation profiles of NSCs treated with IL‐18 and/or melatonin (10 ng/ml) in the absence or presence of TrkB‐Fc. (B) The profiles of neurosphere formation. (C) Immunofluorescence staining for profiles of β‐tubulin‐III‐positive neurons derived from NSCs. (D) mRNA and (E) protein levels of β‐tubulin‐III, respectively. *P < 0.05; **P < 0.01 and ***P < 0.001.
