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. 2017 Aug 24;17:77. doi: 10.1186/s12935-017-0446-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Recruitment of HIF-1α and ARNT to the ARNT gene promoter. a Functional elements within the ARNT promoter sequence upstream to −1200 bp from the transcription start site (bp 1). HBS HIF binding site, HAS HIF ancillary sequence, TATA TATA box. Investigated partial sequences are indicated (Region 1, Region 2, Region 3). b Chromatin immunoprecipitation (ChIP) assays. Values are presented as mean ± SEM of n = 3 independent experiments. IgG normal rabbit IgG, H3 histone H3