Table 2.
The hepatic level of IL-6 (pg/mg protein), TNF-alpha (pg/mg protein), PGE2 (μg/mg protein), and COX-2 activity (nmol/min/mg protein) in normal (N) or diabetic mice (D) treated with RA at 0, low, or high dose for 9 weeks. Values are mean ± SD, n = 8. a-dmeans in a row without a common letter differ statistically, p < 0.05.
| N | D | D + RA, low | D + RA, high | |
|---|---|---|---|---|
| IL-6 | 40 ± 5a | 103 ± 9b | 54 ± 8a | 46 ± 4a |
| TNF-alpha | 4.8 ± 0.6a | 8.3 ± 1.0b | 5.2 ± 0.3a | 5.1 ± 0.5a |
| PGE2 | 6.4 ± 0.4a | 19.5 ± 1.1c | 14.4 ± 0.7b | 12.9 ± 0.9b |
| COX-2 | 1.8 ± 0.2a | 16.8 ± 0.8d | 11.1 ± 1.0c | 5.7 ± 0.6b |