Fig. 5.

The cost-effectiveness (cost per life year gained) of all evaluated scenarios and the scenarios that constitute an efficient frontier. The figure illustrates three scenarios judged to be efficient based on the cost per life year gained ratio. These scenarios constitute the efficient frontier. The other 73 evaluated scenarios are illustrated according to the population selection criteria and applied nodule management protocol (NMP). The figure illustrates the four evaluated eligibility criteria in different colours: 55-75-40-10 is given in green, 55-74-30-15 is given in violet, 55-80-30-15 is given in orange and 50-75-15-9 is given in dark blue. The scenarios which apply the NLST-like nodule management are illustrated with a circular shape. The scenarios which apply the NELSON-like nodule management are illustrated with a triangular shape. The figure does not specify in colour or a shape the evaluated variations of the threshold values for the tumour size and growth in the NELSON-like and NLST-like scenarios. The scenarios which resemble the eligibility criteria and nodule management protocols of the NLST and NELSON clinical trials are illustrated in light blue. Descriptions of the scenarios are given in Table 1. Main outcomes and cost-effectiveness of the 76 baseline screening scenarios are given in Additional file 1: Table S12