Table 4.

Association of Urinary Sodium with Systolic Strain and Early Diastolic Tissue Velocity in Participants with Estimate Sodium Intake >3.7 g/day on Mediation Analysis

Dependent variable	Model 2†			Model 3‡
	β-Coefficient (95% CI)	P-value	Proportion Explained by Systolic Blood Pressure	β-Coefficient (95% CI)	P-value	Proportion Explained by Serum Aldosterone
Longitudinal strain, %	−0.36 (−0.68, −0.04)	0.027	14%*	−0.34 (−0.66, −0.02)	0.039	19%*
Circumferential strain, %	−0.49 (−1.00, 0.01)	0.057	6%	−0.55 (−1.07, −0.04)	0.035	−6%
STe′, cm/s	−0.12 (−0.24, −0.00)	0.048	20%*	−0.14 (−0.26, −0.02)	0.025	7%

CI, confidence interval, STe′, speckle-tracking derived early diastolic tissue velocity. All strain parameters are reported as absolute values. Beta-coefficients reflect the change in the dependent variable per 1 gram/day increase in estimated sodium intake.

All models adjusted for age, sex, smoking status, alcohol use, blocks walked per day, diuretic use, estimated glomerular filtration rate, left ventricular mass, wall motion abnormalities, ejection fraction, center, speckle-tracking analyst, and image quality.

^*Statistically significant change in model with addition of intermediary factor (p<0.05).

^†Additional adjustment for systolic blood pressure.

^‡Additional adjustment for serum aldosterone.