Table 4. Percent breast density (BD) from clinical mammography (4a.) and FWR-MRI-based breast density (range 0-1, higher number indicates higher density) (4b.) baseline and after 12 months on study, by arm.
| 4a. BD by mammography | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| Time point | Placebo | DIME | ||||
|
|
|
|||||
| n | Mean ± SD | Median | n | Mean ± SD | Median | |
| First mammogram | 49 | 26.3 ± 14.2 | 23.9 | 53 | 23.9 ± 15.5 | 18.8 |
| Follow-up mammogram | 41 | 25.4 ± 13.9 | 24.4 | 45 | 22.4 ± 15.2 | 19.2 |
| Change (P = 0.744) a | 41 | −1.9 ± 7.4 | 45 | −1.3 ± 7.6 | ||
|
| ||||||
| 4b. BD by FWR MRI | ||||||
|
| ||||||
| Time point | Placebo | DIM | ||||
|
|
|
|||||
| n | Mean ± SD | Median | n | Mean ± SD | Median | |
|
| ||||||
| Baseline | 37 | 0.32 ± 0.20 | 0.24 | 34 | 0.31 ± 0.26 | 0.20 |
| 12 months | 33 | 0.31 ± 0.18 | 0.26 | 27 | 0.28 ± 0.24 | 0.20 |
| B to 12 mo (P=0.772)b | 30 | −0.008 ± 0.1 | 24 | −0.001 ± 0.1 | ||
a
t-test for differences in change between placebo and DIM groups
b
Δ B to 12 months = 12 month minus the baseline value