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. Author manuscript; available in PMC: 2017 Aug 25.
Published in final edited form as: J Biol Rhythms. 2017 May 3;32(3):195–211. doi: 10.1177/0748730417700458

Figure 1. Synthesis of N-acetyltryptamine and melatonin from tryptophan.

Figure 1

The biosynthesis of N-acetyltryptamine from tryptophan by a pathway sharing enzymes with the melatonin pathway. TPH1, tryptophan hydroxylase-1; DDC, dopa decarboxylase; AANAT, arylalkylamine -acetyltransferase; NAT1, arylamine N-acetyltransferase 1; NAT2, arylamine N-acetyltransferase 2; ASMT, acetylserotonin O-methyltransferase; HIOMT, hydroxyindole-O-methyltransferase.