Table 3.
Mean (SE) percent differences between the supplement and placebo groups, split by sexa.
Model 1b |
Model 2c |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Females |
Males |
Sex*supplement interaction p = | Females | Males | Sex*supplement interaction p = |
|||||
Mean difference (SE) % | p-Value | Mean difference (SE) % | p-Value | Mean difference (SE) % | p-Value | Mean difference (SE) % | p-Value | |||
Height | − 1.0 (0.5) | 0.04 | 0.5 (0.5) | 0.3 | 0.03 | – | – | – | – | – |
HAZd | − 0.2 (0.1) | 0.04 | 0.1 (0.1) | 0.3 | 0.02 | – | – | – | – | – |
Weight | − 3.3 (1.5) | 0.03 | 2.2 (1.6) | 0.2 | 0.01 | – | – | – | – | – |
MUACe | − 1.8 (1.0) | 0.04 | 2.0 (1.0) | 0.05 | 0.007 | − 0.2 (0.5) | 0.7 | 1.0 (0.6) | 0.09 | 0.1 |
TSTf | − 1.5 (3.0) | 0.6 | 4.7 (3.1) | 0.1 | 0.1 | 1.1 (2.5) | 0.7 | 3.0 (2.6) | 0.2 | 0.6 |
Whole body | ||||||||||
BMC | -4.6 (2.2) | 0.03 | 2.8 (2.2) | 0.2 | 0.02 | − 0.3 (0.6) | 1.0 | 0.5 (0.6) | 0.4 | 0.5 |
Bone area | − 3.3 (1.4) | 0.02 | 1.6 (1.5) | 0.3 | 0.02 | − 0.3 (0.7) | 0.6 | − 0.9 (0.8) | 0.9 | 0.8 |
Lean mass | − 2.4 (1.4) | 0.08 | 1.1 (1.4) | 0.4 | 0.07 | 0.4 (1.0) | 0.7 | 0.1 (1.0) | 0.9 | 0.7 |
Fat mass | − 4.8(4.9) | 0.3 | 11.6 (5.5) | 0.02 | 0.02 | − 2.1 (4.8) | 0.7 | 10.0 (4.9) | 0.04 | 0.08 |
Lumbar spine | ||||||||||
BMC | -4.4 (2.1) | 0.03 | 3.9 (2.3) | 0.09 | 0.007 | − 1.5 (0.2) | 0.4 | 2.0 (1.8) | 0.3 | 0.2 |
Bone area | − 1.9 (1.2) | 0.1 | 2.1 (1.3) | 0.1 | 0.03 | − 0.4 (1.0) | 0.7 | 1.2 (1.1) | 0.3 | 0.3 |
Total hip | ||||||||||
BMC | -5.5 (2.3) | 0.02 | 0.5 (2.5) | 0.8 | 0.07 | − 1.6 (1.6) | 0.3 | − 1.7 (1.7) | 0.3 | 0.9 |
Bone area | − 3.1 (1.5) | 0.04 | − 0.0 (1.5) | 0.9 | 0.1 | − 0.9 (1.0) | 0.4 | − 1.1 (1.0) | 0.3 | 0.9 |
Tibia | ||||||||||
Total vBMD | − 2.8 (4.7) | 0.6 | 2.7 (4.7) | 0.6 | 0.4 | − 0.4 (1.5) | 0.8 | 0.4 (1.5) | 0.8 | 0.7 |
Midshaft CSA | − 3.7 (1.7) | 0.03 | 2.2 (1.8) | 0.2 | 0.02 | − 1.2 (1.4) | 0.4 | 0.9 (1.4) | 0.5 | 0.3 |
BMC | − 3.6 (1.9) | 0.06 | 1.7 (1.9) | 0.4 | 0.04 | − 1.2 (1.6) | 0.5 | 0.7 (1.7) | 0.7 | 0.4 |
Cortical area | − 4.1 (1.7) | 0.02 | 1.9 (1.8) | 0.3 | 0.01 | − 1.7 (1.5) | 0.2 | 0.8 (1.5) | 0.6 | 0.2 |
Differences between children whose mothers took calcium versus those who had placebo were tested using linear models with the following covariates.
Sex, supplement, current age, length at 52 weeks, sex*supplement interaction.
Sex, supplement, current age, length at 52 weeks, sex*supplement interaction, current height and weight, and DXA BMC bone area. All continuous variables were in natural logarithms.
HAZ height-for-age Z score calculated from WHO reference [15].
MUAC Mid-upper arm circumference.
TST Triceps skinfold thickness.