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. 2017 Aug 25;12(8):e0183469. doi: 10.1371/journal.pone.0183469

Fig 6. Trp53/Pten undifferentiated pleomorphic sarcomas demonstrate immune tolerance.

Fig 6

A) Histology of UPS reveals an infiltrate of small mature lymphocytes (arrow), which is further confirmed by immunohistochemistry for CD45 (B, arrow). Immunohistochemistry was performed for PD-L1 (B7-H1), showing expression patterns ranging from focal/variable staining (C), to diffusely and strongly positive (D), suggesting that UPS in the Trp53/PTEN model are immunogenic and might evade immunosurveillance by PD-L1 upregulation.