Table 3. Univariate analyses with CCS as end-point.

Variable	Hazard ratio	(95% CI)	p-value
Age (per year)	1.04	(1.01–1.07)	0.015
Tumour size	1.41	(1.04–1.90)	0.026
FIGO stage (III-IV vs I-II)	2.54	(1.62–5.54)	0.019
Localisation (whole vs upper vagina)	3.47	(1.42–8.47)	0.010
Tumour grade (3 vs 1)	1.80	(0.66–4.89)	ns
Histology (adeno vs SSC)	0.62	(0.19–2.02)	ns
HPV status (negative vs positive)	4.01	(1.96–8.21)	<0.001
LRIG1 (>50% vs <50% positive cells)	0.35	(0.68–0.73)	0.011