Fig 4. Pathways affected by pathological mutations in RAS/MAPK proteins predicted to be at binding hot-spots.

Proteins of the RAS/MAPK pathway are shown as colored circles, showing pathological mutations that were not previously characterized due to the lack of structural data, but that have been predicted here to be binding hot-spots for docking partner proteins involved in other pathways (linked to the corresponding mutation). Pathways shown in red are those that could not have been found using only available structural data.