Association of 48 SNP polygenic risk score for WHRadjBMI with type 2 diabetes and coronary heart disease. Results are standardized to a one SD increase in WHRadjBMI due to polygenic risk score. Estimates were independently derived in genome-wide association studies (CARDIOGRAMplusC4D for coronary heart disease and DIAGRAM for type 2 diabetes) and UK Biobank. The threshold of significance was p< 0.025 (0.05/2=0.025). Error bars refer to the 95% confidence interval for each estimate. Size of data marker is inversely proportional to variance of estimate. Abbreviations: OR, odds ratio; SD, standard deviation; SNPs, single nucleotide polymorphisms; WHRadjBMI, waist-to-hip ratio adjusted for body mass index; CHD, coronary heart disease; T2D, type 2 diabetes; CARDIOGRAMplusC4D, Coronary ARtery DIsease Genome-wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics consortium; DIAGRAM, DIAbetes Genetics Replication And Meta-analysis.