Table 3.
The fractional inhibitory concentrations index (FICI) of the combinations of antimicrobial agents against Staphylococcus aureus.
| Antibiotics | FICI |
Interaction | |||
|---|---|---|---|---|---|
| combination | ATCC 29213 | ATCC 43300 | N54 | N9 | |
| VAL+CTX | 2 | 2 | 2 | 2 | Indifferent |
| VAL+ERY | 2 | 2 | 2 | 2 | Indifferent |
| VAL+FFC | 1.5 | 1.5 | 2 | 2 | Indifferent |
| VAL+CLI | 2 | 2 | 2 | 2 | Indifferent |
| VAL+CIP | 5 | 5 | 4 | 5 | Antagonistic |
| VAL+ENR | 5 | 5 | 4 | 5 | Antagonistic |
| VAL+GEN | 2 | 2 | 2 | 2 | Indifferent |
| VAL+AMK | 2 | 2 | 2 | 2 | Indifferent |
| VAL+TET | 0.375 | 0.5 | 0.5 | 0.5 | Synergistic |
| VAL+VAN | 2 | 2 | 2 | 2 | Indifferent |
| VAL+BCR | 1.5 | 2 | 2 | 2 | Indifferent |
| VAL+SMZ | 2 | 2 | 2 | 2 | Indifferent |
| VAL+TMP | 2 | 2 | 2 | 2 | Indifferent |
| TIA+TET | 0.5 | 0.75 | 0.75 | 0.75 | Synergistic or additivity |
| RET+TET | 0.5 | 0.5 | 0.5 | 0.5 | Synergistic |
| TIA+CIP | 4 | 4 | 4 | 4 | Antagonistic |
| TIA+ENR | 4 | 4 | 4 | 4 | Antagonistic |
| RET+CIP | 4 | 4 | 4 | 4 | Antagonistic |
| RET+ENR | 4 | 5 | 5 | 5 | Antagonistic |
CTX, cefotaxime; ERY, erythromycin; FFC, florfenicol; CLI, clindamycin; CIP, ciprofloxacin; ENR, enrofloxacin; GEN, gentamicin; AMK, amikacin; TET, tetracycline; VAL, valnemulin; TIA, tiamulin; RET, retapamulin; VAN, vancomycin; BCR, bacitracin; SMZ, sulfamethoxazole; TMP, trimethoprim; ATCC 29213 and N54: MSSA; ATCC 4330 and N9: MRSA.