Table 1.

Clinicopathological and mutation information of primary leptomeningeal melanocytic tumors

Nr.	Age	Sex	Location	Diag.	Sample	GNAQ	GNA11	PLCB4	CYSLTR2	EIF1AX	SF3B1	BAP1	Status	FU
1	46	f	cavernous sinus	M	P	-	-	-	-	-	-	-	NK	NK
2	48	f	spinal	M	P	Q209L°	-	-	-	-	-	-	NK	NK
3	41	f	frontal	M	P	Q209P°	-	-	-	-	-	-	NK	NK
4	73	m	spinal C2-3	M	P	Q209L	-	-	-	-	-	-	NK	NK
5	73	f	temporal right	M	P	-	-	D630Y	-	-	-	E31del	NK	NK
6	77	f	spinal T7-8	M	P	-	-	-	L129Q	R13C	-	-	NK	NK
7	34	m	spinal T10-12	IGM	P	Q209P	-	-	-	-	-	-	A	7y
8	44	m	spinal C1	IGM	P	Q209L°	-	-	-	-	-	-	A	5y
9	79	m	spinal T4-5	IGM	R	Q209L°	-	-	-	-	-	-	NK	NK
10	35	f	spinal C5-6	IGM	P	Q209P°	-	-	-	-	-	-	A	8y
11	65	m	spinal C3	IGM	P	Q209L°	-	-	-	G8V	-	-	A	3y
12	69	f	spinal T8	IGM	P	Q209L°	-	-	-	G9D	-	-	NK	NK
13	64	m	spinal C5	IGM	P	Q209L°	-	-	-	-	-	-	NK	NK
14	NK	NK	NK	IGM	P	Q209L	-	-	-	-	-	-	NK	NK
15	20	m	frontal	IGM	P	Q209P°	-	-	-	-	-	-	A, R#	5y
16	67	m	spinal T9-10	IGM	P	-	-	-	L129Q	-	-	-	NK	NK
17	48	f	spinal T8-9	IGM	R	-	Q209L°	-	-	R13P	-	-	A	6y
18	78	f	tentorium	IGM	P	-	Q209L°	-	-	-	-	R60*°	R§	1y
19	66	m	brain	Mel	P	R183Q°	-	-	-	G15D	R625H°	-	D	1y

green = activating mutations; blue = mutations expected to alter protein function; red = loss of function mutation; grey = mutation of unclear functional significances; Nr. = number; Diag. = diagnosis; m = male; f = female; NK = not known; P = primary; R = recurrence; M = melanocytoma; IGM = intermediate grade melanocytoma; Mel = melanoma; del. = deletion; FU = follow-up period; NK = not known; A = alive; R^# = recurred after 3 years (mutation profile was identical to the primary); R^§ = recurred, then lost to follow-up; D = dead (disease related)

^°signifies mutations previously published (van de Nes et al., 2016a, van de Nes et al., 2016b)