Table 3.
Leave-one-out prediction error for a range of metrics at a CL of 2,000 ms and 3 doses (1, 10, and 20x Cmax): resting membrane potential (resting Vm), maximum upstroke velocity (dV/dtmax), peak membrane potential (peak Vm), APD at 50 and 90% of the amplitude (APD50 and APD90), action potential (AP) triangulation (APDtri), diastolic intracellular calcium concentration ([Ca2+]i) (diastolic Ca), peak [Ca2+]i (peak Ca), calcium transient duration at 50 and 90% of the amplitude (CaD50 and CaD90), calcium transient triangulation (Catri), change in amount of charge carried by INaL and ICaL (cqInward) (Li et al., 2017) and charge carried by the net current (qNet).
| Metric | Leave-one out prediction error | ||
|---|---|---|---|
| 1x Cmax | 10x Cmax | 20x Cmax | |
| qNet | 0.17 | 0.08 | 0.08 |
| cqInward | 0.25 | 0.33 | 0.33 |
| Catri | 1.25 | 1.08 | 1.08 |
| CaD90 | 1.42 | 1.42 | 0.83 |
| CaD50 | 1.42 | 1.0 | 0.83 |
| peak Ca | 0.92 | 0.75 | 0.83 |
| diastolic Ca | 0.92 | 0.83 | 0.83 |
| APDtri | 0.5 | 0.67 | 0.58 |
| APD90 | 0.17 | 0.5 | 0.5 |
| APD50 | 0.33 | 0.33 | 0.5 |
| peak Vm | 0.42 | 0.42 | 0.42 |
| dV/dtmax | 0.42 | 0.83 | 1.17 |
| resting Vm | 1.00 | 0.75 | 0.75 |