Table 4.
Correlation (using pearson method) between qNet, APD90 and cqInward and IKr reduction threshold for the 11 drugs (diltiazem is not included because EADs could not be induced for the highest IKr reduction tested 99.99%) for a CL of 2,000 ms across all doses from 0.5 to 25x Cmax. Simulations where the IKr reduction threshold is 0 (EADs occur without added IKr reduction, as for quinidine ≥ 2.3x Cmax) and results where the IKr reduction threshold could not be calculated (the maximum IKr reduction tested, 99.99%, did not trigger an EAD, as for diltiazem at all Cmax, verapamil ≥ 1.7x Cmax, and mexiletine ≥ 3.8x Cmax) were excluded.
| Drug | Correlation with IKr reduction threshold | ||
|---|---|---|---|
| qNet | APD90 | cqInward | |
| Quinidine | 0.996 | −0.994 | −0.197 |
| Bepridil | 0.948 | −0.992 | 0.432 |
| Sotalol | 0.979 | −0.992 | −0.971 |
| Dofetilide | 0.96 | −0.993 | −1 |
| Cisapride | 0.988 | −0.996 | −0.994 |
| Ondansetron | 0.997 | −0.999 | −0.595 |
| Terfenadine | 0.968 | −0.944 | 0.804 |
| Chlorpromazine | 0.995 | −1 | 0.895 |
| Ranolazine | 0.87 | −0.992 | 0.961 |
| Verapamil | 0.977 | 0.998 | −0.991 |
| Mexiletine | 0.974 | 0.989 | −0.983 |