Table 1. Clinicopathological features from 59 EAC patients of cohort #1.
| Patients | n=59 | BMDTCpositive | BMDTCnegative | LNDTCpositive | LNDTCnegative |
|---|---|---|---|---|---|
|
Sex | |||||
| Male | 47 (ø=64 years) | 8 (19%) | 34 (81%) | 9 (43%) | 12 (57%) |
| Female | 12 (ø=65 years) | 5 (45%) | 6 (55%) | — | 1 (100%) |
|
Primary tumour | |||||
| pTx | 1 | — | 1 (100%) | — | — |
| pT1–2 | 26 | 3 (13%) | 20 (87%) | 5 (45%) | 6 (55%) |
| pT3–4 | 32 | 10 (34%) | 19 (66%) | 4 (36%) | 7 (64%) |
|
Lymph node statusa | |||||
| pN0 | 16 | — | 14 (100%) | 2 (40%) | 3 (60%) |
| pN1–3 | 43 | 13 (33%) | 26 (66%) | 7 (41%) | 10 (59%) |
|
Distant organ metastasis | |||||
| M0 | 48 | 12 (29%) | 30 (71%) | 8 (47%) | 9 (53%) |
| M1 | 11 | 1 (9%) | 10 (91%) | 1 (20%) | 4 (80%) |
|
Tumour grade | |||||
| Gx | 2 | — | 2 (100%) | — | — |
| G2 | 21 | 6 (32%) | 13 (68%) | 4 (57%) | 3 (43%) |
| G3 | 36 | 7 (22%) | 25 (78%) | 5 (33%) | 10 (67%) |
|
Resection margins | |||||
| R0 | 52 | 13 (28%) | 34 (72%) | 9 (43%) | 12 (57%) |
| R1 | 6 | — | 5 (100%) | — | 1 (100%) |
| R2 | 1 | — | 1 (100%) | — | — |
|
Neoadjuvant therapy | |||||
| 13 | 2 (15%) | 11 (85%) | 1 (25%) | 3 (75%) | |
Abbreviations: BMDTC=disseminated tumour cell from the bone marrow; EAC=oesophageal adenocarcinoma; LNDTC=disseminated tumour cell from the lymph node.
a
The presence of DTCs significantly correlated (P=0.03) to LN metastases.