Table 2. Association between leukocyte telomere length (LTL) and disease-specific survival among renal cell carcinoma patients from the US Kidney Cancer Study (USKC) and the prostate, lung, colorectal and ovarian cancer (PLCO) screening triala.
| Quartile of LTL | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
Q4 |
Q3 |
Q2 |
Q1 |
||||||
| Study | n (event) | HR | n (event) | HR (95% CI) | n (event) | HR (95% CI) | n (event) | HR (95% CI) | Ptrend |
| USKC | |||||||||
| Model 1b | 171 (20) | 1.0 | 171 (24) | 1.3 (0.7–2.4) | 171 (21) | 1.1 (0.6–2.0) | 171 (31) | 1.7 (0.9–3.0) | 0.13 |
| Model 2c | 1.0 | 1.5 (0.7–3.0) | 1.7 (0.8–3.5) | 2.3 (1.2–4.4) | 0.02 | ||||
| PLCOd | 60 (15) | 1.0 | 60 (11) | 1.0 (0.4–2.5) | 57 (14) | 2.0 (0.8–4.9) | 64 (22) | 2.4 (1.0–5.4) | 0.04 |
| Years from blood draw | |||||||||
| ⩽6.5 | 27 (9) | 1.0 | 19 (4) | 0.6 (0.1–2.4) | 32 (9) | 1.9 (0.5–7.8) | 29 (7) | 1.4 (0.3–6.1) | 0.75 |
| >6.5 | 33 (6) | 1.0 | 41 (7) | 0.8 (0.2–3.0) | 25 (5) | 2.0 (0.4–10.5) | 35 (15) | 3.4 (0.9–13.2) | 0.04 |
| Combinede | 1.0 | 1.2 (0.7–2.0) | 1.8 (1.1–3.0) | 2.3 (1.3–4.1) | 0.002 | ||||
Analyses were performed using study-specific Cox proportional hazards models, study-specific cut points for LTL were based on quartiles of all cases included in these analyses as follows: USKC: Q1⩽0.73, Q2 0.73–0.85, Q3 0.85–1.01, Q4>1.01; PLCO Q1⩽1.00, Q2 1.00–1.21, Q3 1.21–1.55, Q4>1.55.
USKC model 1 was adjusted for age, sex, race, hypertension, smoking status, body mass index, education, and source of DNA (buffy coat vs whole blood).
USKC model 2 was adjusted for age, sex, race, hypertension, smoking status, body mass index, education, source of DNA (buffy coat vs whole blood), histologic subtype (clear cell, papillary, chromophobe, cystic or other), tumour size (⩽4 cm, 4.1–7 cm, or >7 cm), treatment (no surgery or adjuvant treatment, surgery only, adjuvant treatment only, or adjuvant treatment and surgery), grade (I, II, III, or missing) and stage (I, II, or III/IV).
PLCO models were adjusted for age, sex, race, hypertension, smoking status, body mass index, education, study center, and source of DNA (buffy coat vs other).
USKC Model 2 and PLCO were combined using random effects meta-analysis, no heterogeneity was observed for any quartile (I2=0.00%).