Table 1.

Non-radioactive Cyanation of a Peptide.^a

entry	L	reaction time of step a (min.)	stoichimotetry of NaCN (equiv.)	yield (%)c
1	L1	10	1	34d
2	L1	10	0.2	46
3	L1	10	0.1	61
4e	L1	10	1	31
5	L1	30	1	33
6f	L1	10	1	31
7	L2	10	1	64
8	L3	10	1	13

^aReaction conditions: 1 (20 nmol), Pd complex (20 nmol), DMSO (200 μL), r.t., 10–30 min.; NaCN (aq.) in 10 μL H₂O, 5 min.

^bAcNH-FLGKGVGCAF-CO₂H.

^cDetermined by integration of HPLC peak area with calibration.

^dAverage of three runs.

^eResults with 1.5 equivalent of Pd complex.

^fResult with 0.1 M Tris buffer in DMSO/H₂O (9:1) in place of DMSO.