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. Author manuscript; available in PMC: 2018 May 31.
Published in final edited form as: J Am Chem Soc. 2017 May 17;139(21):7152–7155. doi: 10.1021/jacs.7b02761

Table 3.

Robustness of the Method.a

graphic file with name nihms894252u4.jpg
entry [peptide] (μM) DMSO/H2O RCY (%)
1 500 90/10 19
2 500 33/67 3
3 500 5/95 4
4 250 90/10 22
5 50 90/10 20
6 10 90/10 19
7 2 90/10 < 1
8b 500 90/10 0
a

Reaction conditions: 1 (1.0 equiv.), Pd complex (1.0 equiv.), 0.1 M Tris buffer in DMSO/H2O (200 μL), r.t., 10 min.; [11C]HCN in H2O (20 μL, 1–10 mCi), r.t., 5 min.

b

Result with AcNH-FLGKGVGSAF-CO2H.