. Author manuscript; available in PMC: 2018 May 31.

Published in final edited form as: J Am Chem Soc. 2017 May 17;139(21):7152–7155. doi: 10.1021/jacs.7b02761

Table 3.

Robustness of the Method.^a


entry	[peptide] (μM)	DMSO/H₂O	RCY (%)
1	500	90/10	19
2	500	33/67	3
3	500	5/95	4
4	250	90/10	22
5	50	90/10	20
6	10	90/10	19
7	2	90/10	< 1
8^b	500	90/10	0

Reaction conditions: 1 (1.0 equiv.), Pd complex (1.0 equiv.), 0.1 M Tris buffer in DMSO/H₂O (200 μL), r.t., 10 min.; [¹¹C]HCN in H₂O (20 μL, 1–10 mCi), r.t., 5 min.

Result with AcNH-FLGKGVGSAF-CO₂H.