Table 3.
Cut-off points and diagnostic performance of M@T and MMSE to discriminate between AD, aMCI.
| Discrimination between early AD and aMCI | Discrimination between aMCI and controls | Discrimination between early AD and controls | |||||||
|---|---|---|---|---|---|---|---|---|---|
| M@T | MMSE | CDT | M@T | MMSE | CDT | M@T | MMSE | CDT | |
| Optimal cut-off § | 26 | 21 | 5 | 35 | 21 | 8 | 29 | 21 | 5 |
| Sensitivity | 100.00 | 86.67 | 100.00 | 99.17 | 90.91 | 95.04 | 100.00 | 90.91 | 100.00 |
| Specificity | 97.53 | 75.31 | 87.65 | 91.11 | 13.33 | 31.11 | 98.77 | 75.31 | 87.65 |
| Correctly classified (%) | 98.41 | 79.37 | 92.06 | 96.99 | 69.88 | 77.71 | 99.50 | 84.65 | 95.05 |
| Likelihood ratio + | 40.500 | 3.51 | 8.10 | 11.16 | 1.05 | 1.38 | 81.00 | 3.68 | 8.10 |
| Likelihood ratio − | 0.000 | 2.07 | 0.00 | 0.009 | 0.68 | 0.16 | 0.000 | 0.12 | 0.00 |
| Area under | 0.9960† | 0.8278 | 1.0000 | 0.9956†‡ | 0.6536 | 0.6869 | 1.0000† | 0.8820 | 1.0000 |
| curve [95% CI] | [0.99–1.00] | [0.76–0.90] | [1.00–1.00] | [0.99–1.00] | [0.57–0.74] | [0.60–0.78] | [1.00–1.00] | [0.83–0.93] | [1.00–1.00] |
AD, Alzheimer’s dementia; aMCI, amnestic mild cognitive impairment; MMSE, Mini Mental State of Examination; M@T, Memory Alteration Test; CI, Confidence interval; §Cut-off base on maximum value of correctly classified. †Significant difference regarding the MMSE (p-value < 0.05); ‡Significant difference regarding the CDT (p-value < 0.05).