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. 2017 Aug 22;8:605. doi: 10.3389/fphys.2017.00605

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Copyright © 2017 Amaral, Miranda, Marcato and Swiech.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentration-response curves: cell viability (%) plotted against the logarithm of the doxorubicin concentration (μg/mL). (A) 2D and 3D ULA cultures seeded with 0.5 × 10⁴ cells/mL; (B) 2D and 3D ULA cultures seeded with 1.25 × 10⁴ cells/mL; (C) 2D and 3D HD cultures seeded with 2.5 × 10⁴ cells/mL; (D) 2D and 3D HD cultures seeded with 3.75 × 10⁴ cells/mL. Curves represent sextuplicate biological repeats and are displayed as mean ± SEM (n = 6).