Table 2.
Unadjusted and adjusted odds ratios for all cause mortality according to current* use of different combinations of aspirin, statins, β blockers, and angiotensin converting enzyme inhibitors, Values are numbers (percentages) unless stated otherwise
| Current use of studied drugs* | Cases (n=2266) | Controls (n=9064) | Unadjusted odds ratio (95% CI) | Adjusted odds ratio†(95% CI) |
|---|---|---|---|---|
| None | 677 (29.9) | 1738 (19.2) | 1.00 | 1.00 |
| Statins alone | 26 (1.1) | 117 (1.3) | 0.48 (0.31 to 0.74) | 0.53 (0.33 to 0.86) |
| Angiotensin converting enzyme inhibitors | 211 (9.3) | 474 (5.2) | 1.14 (0.94 to 1.37) | 0.80 (0.65 to 0.99) |
| Aspirin alone | 420 (18.5) | 1830 (20.2) | 0.58 (0.51 to 0.67) | 0.59 (0.50 to 0.68) |
| β blockers alone | 109 (4.8) | 440 (4.9) | 0.63 (0.50 to 0.79) | 0.81 (0.63 to 1.04) |
| Statins or angiotensin converting enzyme inhibitors | 35 (1.5) | 65 (0.7) | 1.14 (0.74 to 1.75) | 0.69 (0.43 to 1.12) |
| Statins and aspirin | 72 (3.2) | 424 (4.7) | 0.37 (0.28 to 0.48) | 0.39 (0.29 to 0.52) |
| Statins and β blockers | 20 (0.9) | 92 (1.0) | 0.48 (0.29 to 0.79) | 0.46 (0.26 to 0.82) |
| Angiotensin converting enzyme inhibitors and aspirin | 256 (11.3) | 852 (9.4) | 0.76 (0.64 to 0.90) | 0.54 (0.45 to 0.66) |
| Angiotensin converting enzyme inhibitors and β blockers | 45 (2.0) | 144 (1.6) | 0.75 (0.53 to 1.06) | 0.64 (0.43 to 0.94) |
| Aspirin and β blockers | 151 (6.7) | 1087 (12.0) | 0.33 (0.27 to 0.41) | 0.38 (0.31 to 0.47) |
| Statins, angiotensin converting enzyme inhibitors, and aspirin | 60 (2.6) | 319 (3.5) | 0.41 (0.31 to 0.56) | 0.29 (0.21 to 0.41) |
| Statins, angiotensin converting enzyme inhibitors, and β blockers | 11 (0.5) | 34 (0.4) | 0.68 (0.34 to 1.37) | 0.67 (0.30 to 1.51) |
| Statins, aspirin, and β blockers | 45 (2.0) | 622 (6.9) | 0.16 (0.11 to 0.22) | 0.17 (0.12 to 0.23) |
| Angiotensin converting enzyme inhibitors, aspirin, and β blockers | 71 (3.1) | 420 (4.6) | 0.41 (0.31 to 0.54) | 0.34 (0.26 to 0.46) |
| Statins, angiotensin converting enzyme inhibitors, aspirin, and β blockers | 57 (2.5) | 406 (4.5) | 0.31 (0.23 to 0.42) | 0.25 (0.18 to 0.35) |
*
Last prescription for drug within 90 days before index date.
†
Adjusted for comorbidity (diabetes, hypertension, congestive cardiac failure, and myocardial infarction), use of calcium channel blockers, smoking status, body mass index (obese, not obese, not recorded), and Townsend score (fifths).