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. 2017 Aug 22;8:422. doi: 10.3389/fneur.2017.00422

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Copyright © 2017 Blonda, Amoruso, Grasso, Di Francescantonio and Avolio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of microvesicle (MV) production between untreated MS and healthy donors (HDs): (A). monocytes-derived MVs released by unstimulated cells Krebs-Ringer solution (KRH); (B) MVs produced by monocytes challenged with benzoyl-ATP (BzATP). Data obtained by spectrophotometric analysis are expressed as mean ± SEM of fluorescence arbritary unit (A.U.); (C) effect of interferon-beta (IFNb) and teriflunomide treatments on monocyte-derived microvescicles in MS patients followed from the baseline up to 12 months of therapy.