Table 2. Univariate associations of markers of CKD severity and three GFR measures.
| Variable | mGFR^ | eGFRCKiDfull | eGFRCKiDbed |
|---|---|---|---|
| UPCR, mg/mg | +169.7% (+139.4% to +203.8%) | +204.0% (+167.2% to +245.9%); P < 0.001 | +155.0% (+129.8% to +182.9%); 0.05 |
| Hemoglobin, g/dL | -7.6% (-8.7% to -6.5%) | -7.9% (-9.0% to -6.7%); 0.1 | -5.7% (-6.7% to -4.7%); <0.001 |
| Phosphate, mg/dL | +9.4% (+7.6% to +11.2%) | +11.1% (+9.2% to +13.0%); <0.001 | +7.3% (+5.7% to +8.9%); <0.001 |
| Bicarbonate, mEq/L | -7.6% (-8.8% to -6.5%) | -8.1% (-9.3% to -6.9%); 0.02 | -6.0% (-7.0% to -4.9%); <0.001 |
| Potassium, mEq/L | +3.3% (+2.2% to +4.4%) | +3.3% (+2.1% to +4.6%); 0.7 | +1.9%; (+0.9% to +3.0%); <0.001 |
| Adjusted SBP z score* | +0.15 (+0.04 to +0.26) | +0.19 (+0.07 to +0.31); 0.009 | +0.13 (+0.03 to +0.24); 0.5 |
| Adjusted DBP z score* | +0.06 (-0.04 to +0.15) | +0.05 (-0.05 to +0.16); 0.6 | 0.00 (-0.10 to +0.09); <0.001 |
| Adjusted height z score** | -0.36 (-0.48 to -0.24) | -0.39 (-0.52 to -0.26); 0.09 | -0.28 (-0.39 to -0.17); 0.002 |
Note: Values are given as univariate associations (95% confidence intervals); P values for 730 children contributing 1539 observations. The measure of association was scaled to a 50% decrease in GFR.
Association and confidence interval values are based on linear regression models accounting for repeated measurements within individuals by generalized estimating equations. P values are based on bootstrap methods.
CKD, chronic kidney disease; GFR, glomerular filtration rate; mGFR, measured GFR (using iohexol); eGFRCKiDfull, GFR estimated with 2012 CKD in Children Study equation based on serum creatinine, cystatin C, and serum urea nitrogen; eGFRCKiDbed, 2009 serum creatinine-based bedside GFR;.UPCR, urinary protein-creatinine ratio
Reference.
Age-, sex-, and height-adjusted.
Age- and sex-adjusted.