Table 3. Longitudinal analysis describing GFR at entry and percent change per year overall, and for varying baseline UPCR based on 3 GFR measures.
| GFR at entry, ml/min/1.73 m2 | Change per year | |||||
|---|---|---|---|---|---|---|
| mGFR | eGFRCKiDfull | eGFRCKiDbed | mGFR | eGFRCKiDfull | eGFRCKiDbed | |
| Overall | 49.9 (48.3 to 51.6) | 51.1 (49.6 to 52.6) | 50.2 (48.6 to 51.9) | -4.3% (-5.0% to -3.5%) | -3.8% (-4.5% to -3.1%) | -6.4% (-7.2% to -5.5%) |
| Baseline UPCR | ||||||
| 0.25 mg/mg (= 43rd percentile) | 52.4 (50.8 to 54.0) | 53.4 (52.0 to 54.9) | 52.8 (51.2 to 54.5) | -4.0% (-4.7% to -3.3%) | -3.4% (-4.0% to -2.7%) | -5.9% (-6.7% to -5.0%) |
| 0.50 mg/mg (= 58th percentile) | 48.0 (46.6 to 49.4) | 49.3 (48.0 to 50.6) | 48.2 (46.7 to 49.7) | -5.1% (-5.8% to -4.3%) | -4.8% (-5.5% to -4.1%) | -7.4% (-8.3% to -6.5%) |
| 1 mg/mg (= 75th percentile) | 43.9 (42.4 to 45.5) | 45.5 (44.0 to 46.9) | 43.9 (42.3 to 45.6) | -6.1% (-7.0% to -5.2%) | -6.2% (-7.1% to -5.3%) | -8.9% (-10.0% to -7.8%) |
| 2 mg/mg (= 88th percentile) | 40.2 (38.5 to 42.1) | 41.9 (40.3 to 43.7) | 40.1 (38.2 to 42.0) | -7.2% (-8.3% to -6.0%) | -7.6% (-8.8% to -6.5%) | -10.4% (-11.7% to -8.9%) |
| 4 mg/mg (= 94th percentile) | 36.9 (34.8 to 39.0) | 38.7 (36.8 to 40.7) | 36.6 (34.5 to 38.8) | -8.2% (-9.7% to -6.7%) | -9.0% (-10.4% to -7.6%) | -11.8% (-13.5% to -10.1%) |
Note: Longitudinal analysis among 730 children contributing 1539 person-visits of longitudinal data. Results are from linear mixed effects models with random intercepts and slopes. Values in parentheses are 95% confidence intervals.
GFR, glomerular filtration rate; mGFR, measured GFR (using iohexol); eGFRCKiDfull, GFR estimated with 2012 CKD in Children Study equation based on serum creatinine, cystatin C, and serum urea nitrogen; eGFRCKiDbed, 2009 serum creatinine–based bedside GFR; UPCR, urinary protein-creatinine ratio.