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FOXP3 as a static T cell regulator independent of Treg status. Cells other than classic Tregs express FOXP3. In the BDC2.5 T cell receptor transgenic mouse model effector, T cells express FOXP3 but in the inflammatory environment where IFNγ, etc., is produced, CD40 is induced on those cells. CD40 interaction with CD154 leads to loss of FOXP3 expression and full effector status.
