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. 2017 Aug 23;8:1591. doi: 10.3389/fmicb.2017.01591

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Copyright © 2017 Pan, Gardner, Pagliai, Gonzalez and Lorca.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mutations N107A, G109A, and E148A in TaP decreases the inhibitory effect of tolfenamic acid on PrbP/DNA interactions. The PrplK probe and 3.5 μM of each of the PrbP mutants (N107A, G109A, and E148A, as indicated in the top of each panel) were incubated with increasing concentrations (0–500 μM) of tolfenamic acid as indicated. TA, tolfenamic acid; First lane of each panel has no protein added. Ratio was calculated by the band intensity of protein: DNA complex and total DNA. Quantification was based on observations from at least 2 replicates.