Figure 1.

Schematic representation to demonstrate difference between naïve and primed bone marrow MSCs. Naïve mesenchymal stem cells are obtained by first isolating the bone-marrow mononuclear cells and then subjecting them to flow cytometry sorting based on promising cell surface markers for naïve MSCs such as CD271. In contrast, the in vitro primed mesenchymal stem cells are procured by initially obtaining the BM-MNCs cell population and then directly subjecting these cells to in vitro serial passaging in high serum containing media.