Figure 5. The relationship between the genes in mice and human samples.

• A
  TG content in the liver tissue of mice fed a zero‐fat high‐sucrose diet (HSD) and chow diet (CD) for 2 weeks (n = 10).
• B–F
  The hepatic mRNA expressions of the Fasn, Pklr, Pcsk9, Pnpla3, and Hmgcr is measured in (B) mice fed a HSD and CD for 2 weeks, (C) Pcsk9 knockout and its littermates (WT) fed a CD for 10 weeks, (D) wild‐type HCC tumor and noncancerous samples, (E) CB₁R knockout HCC tumor and noncancerous samples, and (F) primary human hepatocytes treated with C75 for 4, 6, 8, and 24 h.

Data information: Data are presented as the means ± standard errors of independent experiments. Student's t‐test; *P < 0.05, **P <0.01, ***P < 0.001 represents a significant difference compared with the value in the control group.