S1P3 slows progression to streptozotocin-induced diabetes in mice. Tail vein non-fasting blood glucose values were monitored in male (A,B) and female (C,D) wild-type and S1P3−/− mice on a C57BL6 background (no significant difference, mean ± SEM). Mice were considered diabetic when glucose values were above 200 mg/dL. n = 10, 10, 5, 5 for wt male, wt female, S1P3−/− male and S1P3−/− female mice, respectively.