Table 2.
Variable | Categories | Combined discovery & confirmation cohorts (n=346) | Validation cohort (n=166) | All patients (n=512) | |||
---|---|---|---|---|---|---|---|
Hazard ratio [95% CI] |
Wald test P-value | Hazard ratio [95% CI] |
Wald test P-value | Hazard ratio [95% CI] |
Wald test P-value | ||
Visceral involvement | Unresectable stage III, distant lymph nodes/soft tissue, lung | 1.0 | <0.001 | 1.0 | 0.008 | 1.0 | <0.001 |
Other visceral involvement | 2.5[1.5;4.1] | 3.5[1.4;8.9] | 2.7[1.8;4.2] | ||||
LDH-ratio | ≤2.5 | 1.0 | <0.001 | 1.0 | <0.001 | 1.0 | <0.001 |
>2.5 | 2.5 [1.7;3.6] | 6.1[3.1;12.3] | 2.8 [2.0;3.9] | ||||
Relative lymphocyte count | <17.5% | 1.9 [1.3;2.8] | <0.001 | 2.4 [1.4;4.4] | 0.003 | 2.0 [1.5;2.8] | <0.001 |
≥17.5% | 1.0 | 1.0 | 1.0 | ||||
Relative eosinophil count | <1.5% | 2.2 [1.5;3.1] | <0.001 | 2.2 [1.2;3.9] | 0.006 | 2.0 [1.5;2.8] | <0.001 |
≥1.5% | 1.0 | 1.0 | 1.0 |
LDH: lactate dehydrogenase; CI: confidence interval.