Table 2.
The expression levels of Anorectic genes altered in EF in female and male FBN rats
| Anorectic genes | Epicardial fat | |||||
|---|---|---|---|---|---|---|
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| ||||||
| Female | Male | |||||
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| Refseq | Symbol | Description | Fold | p value | Fold | p value |
| NM_012737 | Apoa4 | Apolipoprotein A-IV | 3.74 | 0.005 | 0.47 | 0.130 |
| NM_012513 | Bdnf | Brain derived neurotrophic factor | 10.3 | 0.001 | 2.82 | 0.340 |
| NM_152845 | Brs3 | Bombesin-like receptor 3 | 16.1 | 0.0001 | 1.81 | 0.393 |
| NM_053816 | Calcr | Calcitonin receptor | 10.4 | 0.0001 | 1.74 | 0.372 |
| NM_013139 | Clps | Colipase, pancreatic | 3.78 | 0.031 | 0.78 | 0.599 |
| NM_031019 | Crh | Corticotropin-releasing hormone | 9.86 | 0.0004 | 1.49 | 0.517 |
| NM_030999 | Crhr1 | Corticotropin-releasing hormone receptor 1 | 8.10 | 0.001 | 1.99 | 0.297 |
| NM_012546 | Drd1a | Dopamine receptor D1A | 10.2 | 0.000 | 3.57 | 0.113 |
| NM_012547 | Drd2 | Dopamine receptor D2 | 6.71 | 0.059 | 22.4 | 0.000 |
| NM_0010348 | Gh1 | Growth hormone 1 | 6.13 | 0.0009 | 1.44 | 0.566 |
| NM_012728 | Glp1r | Glucagon-like peptide 1 receptor | 7.74 | 0.002 | 1.79 | 0.454 |
| NM_139193 | Prlhr | Prolactin-releasing hormone receptor | 10.1 | 0.000 | 1.39 | 0.665 |
| NM_012706 | Grpr | Gastrin-releasing peptide receptor | 10.5 | 0.004 | 4.66 | 0.017 |
| NM_017018 | Hrh1 | Histamine receptor H 1 | 3.51 | 0.030 | 0.79 | 0.493 |
| NM_012765 | Htr2c | 5-Hydroxytryptamine (serotonin) receptor 2C | 10.3 | 0.007 | 4.47 | 0.161 |
| NM_012596 | Lepr | Leptin receptor | 1.27 | 0.570 | 2.80 | 0.040 |
| NM_001025270 | Mc3r | Melanocortin 3 receptor | 29.6 | 0.0002 | 4.65 | 0.330 |
| XM_218815 | Nmb_ | Neuromedin B | 0.04 | 0.0001 | 0.39 | 0.399 |
| NM_012799 | Nmbr | Neuromedin B receptor | 3.77 | 0.003 | 1.02 | 0.968 |
| NM_023100 | Nmur1 | Neuromedin U receptor 1 | 2.23 | 0.394 | 0.05 | 0.021 |
| NM_021589 | Ntrk1 | Neurotrophic tyrosine kinase, receptor, type 1 | 4.11 | 0.004 | 1.07 | 0.896 |
| XM_345484 | Ntsr1 | Neurotensin receptor 1 | 1.67 | 0.171 | 7.62 | 0.002 |
| NM_012719 | Sstr1 | Somatostatin receptor 1 | 9.56 | 0.000 | 1.97 | 0.369 |
| NM_013046 | Trh | Thyrotropin-releasing hormone | 4.69 | 0.000 | 1.11 | 0.864 |
| NM_013047 | Trhr | Trh receptor | 6.70 | 0.003 | 0.31 | 0.115 |
| NM_019150 | Ucn | Urocortin | 9.87 | 0.000 | 1.24 | 0.717 |
| NM_017338 | Calcα | Calcitonin/calcitonin-related polypeptide, alpha | 0.32 | 0.015 | 0.19 | 0.040 |
| NM_001003929 | Cntfr | Ciliary neurotrophic factor receptor | 0.04 | 0.006 | 0.58 | 0.563 |
| NM_172092 | Gcgr | Glucagon receptor | 0.39 | 0.201 | 0.86 | 0.878 |
| NM_017019 | Il1a | Interleukin 1 alpha | 0.20 | 0.000 | 0.29 | 0.036 |
| NM_031512 | Il1b | Interleukin 1 beta | 0.10 | 0.022 | 0.18 | 0.298 |
| NM_017020 | Il6r α | Interleukin 6 receptor, alpha | 0.02 | 0.00005 | 5.51 | 0.170 |
| NM_017071 | Insr | Insulin receptor | 0.09 | 0.014 | 0.84 | 0.911 |
| NM_013076 | Lep | Leptin | 0.12 | 0.027 | 5.35 | 0.254 |
| NM_139326 | Pomc | Proopiomelanocortin | 0.20 | 0.005 | 0.75 | 0.812 |
| NM_020100 | Ramp3 | Receptor activity modifying protein 3 | 0.36 | 0.233 | 3.41 | 0.136 |
| XM_342317 | Sort1 | Sortilin 1 | 0.09 | 0.038 | 1.13 | 0.930 |
| NM_012659 | Sst | Somatostatin | 0.88 | 0.894 | 0.14 | 0.039 |
| NM_012675 | Tnf | Tumor necrosis factor | 0.32 | 0.217 | 1.70 | 0.500 |
The variations in expression profile of anorectic genes between younger and aged rats are expressed as fold changes. Two-tailed Student’s t test was used to analyze the statistical significance. The gene changes that reached statistical significance are in italics