Table 4.

The correlation of obesity-related genes in EF to the body and heart weights of female and male FBN rats

Body weight
Female	Young		Aging		Male	Young		Aging
Genes	r	p value	r	p value	Genes	r	p value	r	p value
Ilia	−0.73	0.036	NS	NS	Adcyaplrl	NS	NS	−0.96	0.018
Mb	−0.76	0.028	NS	NS	Grpr	NS	NS	−0.98	0.011
					Ilia	NS	NS	−0.96	0.043
					Nmurl	NS	NS	−0.96	0.043
Heart weight
Adcyap1	NS	NS	0.81	0.014	Drd2	0.90	0.033	NS	NS
Adrβ1	−0.74	0.036	NS	NS
Apoa4	NS	NS	0.76	0.027
C3	−0.87	0.004	NS	NS
Cnr1	−0.74	0.035	NS	NS
Crh	NS	NS	0.73	0.038
Mchr1	NS	NS	0.81	0.014
Hcrtr1	NS	NS	0.78	0.022
Il1a	NS	NS	0.74	0.035
Nmb	NS	NS	0.81	0.014
Nmbr	NS	NS	0.81	0.014
Pomc	−0.88	0.003	NS	NS
Sort1	−0.85	0.006	NS	NS
Thrb	−0.77	0.026	NS	NS
Trh	NS	NS	0.81	0.014
Trhr	NS	NS	0.79	0.020
Ucn	NS	NS	0.81	0.014

The obesity-related genes that were significantly altered in the EF were correlated to the body weights (average BW = female: 6 months = 230 ± 14 g; 30 months = 320 ± 20 g; male: 6 months = 422 ± 42 g; 36 months = 450 ± 35 g) and heart weights (average HW = female: 6 months = 0.7 ± 0.03 g; 30 months = 1.16 ± 0.03 g; male: 6 months = 1.08 ± 0.03 g; 36 months = 1.7 ± 0.13 g) [9] of the young and aging rats using Pearson’s correlation. The two-tailed p value <0.05 indicated statistical significance. The gene changes that reached statistical significance are emphasized in italics r correlation coefficient, NS no significance