Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 25;7:9520. doi: 10.1038/s41598-017-10422-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Heterogeneity of Aβ proteoforms in the human Alzheimer’s disease brain. (A) Top: full protein sequence of amyloid precursor protein with Aβ1–42 sequence highlighted (grey). Left: Identified Aβ proteoform sequence names, with blue bars representing the alignment with canonical Aβ. Right: Heatmap and quantification of the log₂ relative intensity of each Aβ proteoform for each of the six severe Alzheimer’s disease brain samples in the soluble aggregate and more insoluble fractions. Far right: Peptide score, indicated confidence of peptide identification³⁸. (B) Frequency of Aβ proteoform amino acid start positions identified in CDR3 cohort; 1 = D, aspartic acid. (C) Frequency of Aβ proteoform amino acid end positions identified in CDR3 cohort; 42 = A, alanine. (D) Frequency of Aβ proteoform lengths identified in CDR3 cohort. Pt., Participant; HMW, high molecular weight; N.D., not detected; Ox., Oxidation; Pyro., Pyro-glutamate; Amm., ammonium ion.