Table 2.

Subhazard ratios for first CVD, ESRD, and death event, among CRIC participants reaching eGFR <30 ml/min/1.73 m²

	CVD Event	ESRD Event	Death Event
Age, per 10-y older	1.18 (1.04–1.32)	0.76 (0.70–0.83)	1.77 (1.41–2.24)
Male sex	0.99 (0.78–1.25)	1.22 (1.01–1.49)	1.15 (0.77–1.71)
Race
Black	0.90 (0.71–1.14)	1.16 (0.93–1.43)	1.69 (1.09–2.62)
Other	0.83 (0.54–1.28)	1.39 (0.99–1.96)	0.82 (0.38–1.76)
White	1.00 (reference	1.00 (reference	1.00 (reference
Hispanic vs non-Hispanic ethnicity	0.89 (0.60–1.32)	0.80 (0.58–1.11)	2.23 (1.20–4.15)
eGFR, per 5-ml/min/1.73 m2 higher	0.96 (0.83–1.11)	0.76 (0.66–0.86)	0.88 (0.69–1.12)
Urine PCR, per 2-fold higher	0.98 (0.92–1.03)	1.34 (1.27–1.41)	0.89 (0.82–0.98)
BMI category
25–29.9 kg/m2	1.07 (0.73–1.58)	0.98 (0.74–1.29)	0.80 (0.43–1.50)
30–35 kg/m2	1.31 (0.90–1.90)	0.84 (0.62–1.14)	0.96 (0.53–1.73)
>35 kg/m2	1.33 (0.92–1.92)	0.76 (0.57–1.03)	1.01 (0.56–1.82)
25 kg/m2	1.00 (reference	1.00 (reference	1.00 (reference
Diabetes	1.69 (1.31–2.18)	0.82 (0.67–1.01)	1.17 (0.77–1.78)
SBP, per 10–mm Hg higher	1.08 (1.03–1.14)	1.03 (0.99–1.08)	0.92 (0.82–1.02)
Any CVD History	2.16 (1.70–2.75)	0.65 (0.52–0.82)	1.04 (0.70–1.53)
Current smoking	1.16 (0.85–1.58)	0.84 (0.65–1.10)	2.01 (1.25–3.25)
Ejection fraction, per 5% greater	0.85 (0.81–0.91)	1.06 (1.00–1.12)	0.98 (0.88–1.10)

Note: Associations reflect sub-hazard ratios (95% confidence intervals) for each outcome, considering all other outcomes as competing risks, and adjusted for all variables shown in the table. Due to missing values detailed in Table 1, population size is 1384. Bold font indicates statistically significant values (p<0.05).

Abbreviations: eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; PCR, protein-creatinine ratio; BMI, body mass index; SBP, systolic blood pressure; CRIC, Chronic Renal Insufficiency Cohort; CVD, cardiovascular disease