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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Biomaterials. 2017 Mar 18;129:152–162. doi: 10.1016/j.biomaterials.2017.03.023

Fig. 6.

Fig. 6

Apparent permeability, Papp, of a variety of paracellularly and transcellularly transported drugs. In general, paracellular transport was increased for cells on eECM with decreased CBD and decreased stiffness, while transcellular transport was unaffected. Caco-2 cells demonstrated enhanced Papp of the paracellularly absorbed ranitidine (Zantac®), nadolol (Corgard®), and atenolol (Tenormin®). No difference in transport was observed for transcellularly absorbed dexamethasone (Decadron®) and naproxen (Aleve®). *p < 0.05, **p < 0.01, ***p < 0.001.