Table 1.

Medications contributing to hypomagnesemia.

Medications contributing to hypomagnesemia	Mechanism
Proton pump inhibitors (e.g. omeprazole)	Decreased intestinal Mg2+ reabsorption via TRPM6(18, 24, 25) Tubulo-interstitial nephritis(26)
Diuretics (e.g. furosemide, thiazide)	↓ lumen positive potential difference in TAL blocking Na+ reabsorption in DCT affects membrane potential(27, 28)
Platinum derivatives (e.g. cisplatin, carboplatin)	Necrotic nephropathy(29) PT and DCT injury(30–33)
Calcineurin inhibitors (e.g. cyclosporine A, tacrolimus)	Downregulation of Claudin-16 downregulation of TRPM6(34–37)
Epidermal growth factor receptor inhibitor (e.g. cetuximab)	Blockade of EGF receptor and lack of TRPM6 stimulation(38, 39)
Antimicrobials (e.g. aminoglycosides, amphotericin B, pentamidine,…)	PT damage, Fanconi syndrome(40, 41)