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. 2017 May 11;31(9):3831–3847. doi: 10.1096/fj.201601291R

Figure 4.

Figure 4.

Expression of the M2, but not M1, isoform of PK is induced by HIF-1 in NP cells. A) Measurement of HIF-1α mRNA after stable transduction of rat NP cells with 2 different lentivirally delivered shRNA sequences targeting HIF-1α (n = 4). B, C) mRNA expression of Pkm1 (B) and Pkm2 (C) in NP cells transduced with HIF-1α shRNAs (n = 3). D–F) Western blot (D) and corresponding densitometric analysis of HIF-1α (E) and PKM2 (F) after stable knockdown of HIF-1α (n = 4). Data are means ± sem. *P < 0.05.